The church, dedicated to the Blessed Virgin of Carmine, was erected in 1319 according to a plaque inside the church.

It was reconstructed, although preserving the original framework, on design of Cristoforo Malagola, called the Galaverna, as well as embellished in decorations and paintings.

The old church of San Biagio, situated on Via Emilia in the area where today the Palazzo Montecuccoli of the Erris rises, was demolished in 1768 and the parish moved to Carmine, the latter assuming the name of San Biagio of Carmine.

The interior with only one nave with six arches per side which host the side altars has a deep apse. The choir and the large cupola were painted by Mattia Preti.

Of the 18th century frescoes by Agostino Mitelli and Angelo Colonna which adorned the vault of the sacristy, today only the central part remains.

Facing the cloister dating back to the 14th century and situated to the side of the church is a small chapel with a beautiful gilded coffered ceiling and a detached fresco depicting the Madonna breast-feeding the Child, attributed to Tommaso da Modena.